5′-Hydroxy-5′-homoaristeromycin: Synthesis and antiviral properties
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منابع مشابه
Synthesis of 5-amino- and 5-hydroxy-3,3-difluoropiperidines.
Synthetic routes toward new 5-amino- and 5-hydroxy-3,3-difluoropiperidines, which are of high interest as building blocks in medicinal chemistry, are described. The key step involves the N-halosuccinimide-induced cyclization of 2,2-difluoro-4-pentenylamines toward 5-halo-3,3-difluoropiperidines, which were used to synthesize 5-amino-3,3-difluoropiperidine. In a second strategy, iodolactonizatio...
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Investigations of the mechanism of pyrimidine nucleotide formation from orotic acid led to the isolation and characterization of an activated ribose phosphate derivative which serves as an intermediate in the overall process. In earlier communications (1) we have described briefly the enzymatic synthesis of this new intermediate, identified as PRPPI (equation (I)), and the occurrence of enzymes...
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A small series of 5-(hetero)aryl-modified nucleoside phosphonates was synthesized via an 8-step procedure including a Wittig reaction and Suzuki-Miyaura coupling. An unanticipated anomerization during phosphonate deprotection allowed us to isolate both anomers of the 5-substituted 2'-deoxy-uridine phosphonates and assess their antiviral activity against a broad panel of viruses.
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The biosynthetic precursor of redox cofactor F420, 7,8-didemethyl-8-hydroxy-5-deazariboflavin, was prepared in four steps from 6-chlorouracil, 2-chloro-4-hydroxybenzaldehyde and bis-isopropylidene protected D-ribose. The latter aldehyde was transformed to the corresponding protected ribitylamine via the oxime, which was submitted to reduction with LiAlH4. Key advantage compared to previous synt...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2018
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2018.03.088